Stage 1 — Live

Leaderboard

Live rankings for The Retroviral Wall Challenge. Scored by CLS (Cross-Lineage Score) — the harmonic mean of classification and ranking performance.

Cross-Lineage Score

CLS = 2 × PR-AUC × WSpearman / (PR-AUC + WSpearman)

Best CLS Score 0.318

0.0 0.25 0.50 0.75 1.0

Current Leader

Aparajeet Shadangi

0.318

CLS

0.596

PR-AUC

0.217

WSpearman

Primary Metric

CLS

Harmonic mean — if either component is near zero, CLS collapses. Both problems must be solved.

Classification

PR-AUC

Separates active from inactive RTs. Random baseline: ~0.37.

Ranking

WSpearman

Efficiency-weighted rank correlation. Floored at 0. Currently unsolved.

Stage 1: Doman Dataset Live

57 RTs, LOFO cross-validation. Classification is partially solved (PR-AUC 0.60–0.66) but ranking remains near zero. Submit by March 31, 2026.

Stage 2: Wet-Lab Validation Coming Soon

Your Stage 1 model is re-evaluated on ~40 new RT candidates with real wet-lab PE efficiency data. Same CLS metric. This determines the winner.

Think you can do better?

The dataset is open. The evaluation is transparent. Break through the wall.