Mandrake Bio
Editors built for elite plant tissue
Crop context and delivery shape the design from the beginning, rather than being imposed on a finished editor
We don't search for proteins, We design them
Our full-stack platform runs from metagenome to validated editor: a richly connected DNA and protein database, function-aware generative models, and an in-house wet lab that closes the loop
Nature shows us what worked
We design what should
Function built into the design
Rather than random generation, we encode each application's biological and biophysical requirements directly into our models, then validate function through purpose-built assays, and every result feeds the next design round, already producing double-digit experimental hit rates
Nature optimized proteins for survival, We optimize them for purpose
That is a fundamentally harder problem, and the one we built Mandrake to solve
Designed to move from possibility to function
Compact editors built around delivery
Size, targeting and cell context become inputs to the design brief, not filters applied at the end
New systems from biological dark matter
TerraBase makes rare architectures searchable so promising systems can move into design and assay
Research
Visit The Assay
ORBIT · RBX1The only RBX1 design rated Strong
In the GEM × Adaptyv RBX1 competition, Mandrake’s ORBIT produced the only submission Adaptyv classified as Strong
Read the result
Protein Language Models: Fluent, but clueless
Four experiments on what protein language models learn, where they fail and why structure and physics still matter
Let's make life programmable
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